Recent scientific publications in which EURL staff are among the co-authors: Acutis, Pier Luigi, et al. “Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene.” Veterinary Research 43 (2012): 1-10. https://link.springer.com/article/10.1186/1297-9716-43-8 Acutis, P. L., et al. “Genetic variability of the PRNP gene in goat breeds from Northern and Southern Italy.” Journal of applied microbiology 104.6 (2008): 1782-1789. https://academic.oup.com/jambio/article-abstract/104/6/1782/6719126 Acutis, Pier Luigi, et al. “Comparative analysis of the prion protein (PrP) gene in cetacean species.” Gene 392.1-2 (2007): 230-238. https://www.sciencedirect.com/science/article/pii/S0378111907000054 Babelhadj, Baaissa, et al. “Prion disease in dromedary camels, Algeria.” Emerging infectious diseases 24.6 (2018): 1029. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004840/ Balkema-Buschmann, Anne, et al. “Intra-and Interspecies Transmission of Atypical BSE− What Can We Learn from It?.” Food Safety 4.4 (2016): 121-129. https://www.jstage.jst.go.jp/article/foodsafetyfscj/4/4/4_2016023/_article/-char/ja/ Bélondrade, Maxime, et al. “Sensitive protein misfolding cyclic amplification of sporadic Creutzfeldt–Jakob disease prions is strongly seed and substrate dependent.” Scientific reports 11.1 (2021): 4058. https://www.nature.com/articles/s41598-021-83630-1 Béringue, Vincent, et al. “Transmission of atypical bovine prions to mice transgenic for human prion protein.” Emerging infectious diseases 14.12 (2008): 1898. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634647/ Béringue, Vincent, et al. “A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission.” Journal of Neuroscience 27.26 (2007): 6965-6971. https://www.jneurosci.org/content/27/26/6965.short Bian, Jifeng, et al. “Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.” Plos Pathogens 17.7 (2021): e1009748. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009748 Bozzetta, Elena, et al. “Comparative performance of three TSE rapid tests for surveillance in healthy sheep affected by scrapie.” Journal of virological methods 173.2 (2011): 161-168. https://www.sciencedirect.com/science/article/pii/S0166093411000371 Bruno, Rosalia, et al. “Strain-Dependent Morphology of Reactive Astrocytes in Human-and Animal-Vole-Adapted Prions.” Biomolecules 13.5 (2023): 757. https://www.mdpi.com/2218-273X/13/5/757 Bruno, Rosalia, et al. “Gerstmann–Sträussler–Scheinker Disease with F198S Mutation Induces Independent Tau and Prion Protein Pathologies in Bank Voles.” Biomolecules 12.10 (2022): 1537 https://www.mdpi.com/2218-273X/12/10/1537 Buschmann, A., et al. “Atypical BSE in Germany—proof of transmissibility and biochemical characterization.” Veterinary microbiology 117.2-4 (2006): 103-116. https://www.sciencedirect.com/science/article/pii/S0378113506002203 Capobianco, Raffaella, et al. “Conversion of the BASE prion strain into the BSE strain: the origin of BSE?.” PLoS pathogens 3.3 (2007): e31. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.0030031 Caramelli, M., et al. “Bovine spongiform encephalopathy in Italian herds.” The Veterinary Record 153.23 (2003): 711. htpps://doi.org/10.1136/vr.153.23.711 Casalone, Cristina, and James Hope. “Atypical and classic bovine spongiform encephalopathy.” Handbook of clinical neurology. Vol. 153. Elsevier, 2018. 121-134. https://www.sciencedirect.com/science/article/pii/B9780444639455000076 Casalone, C., et al. “BSE immunohistochemical patterns in the brainstem: a comparison between UK and Italian cases.” Acta Neuropathologica 111 (2006): 444-449. htpps://doi.org/10.1007/s00401-005-0012-1 Casalone, Cristina, et al. “Pathological prion protein in the tongues of sheep infected with naturally occurring scrapie.” Journal of virology 79.9 (2005): 5847-5849. htpps://doi.org/10.1128/JVI.79.9.5847-5849.2005 Casalone, Cristina, et al. “Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease.” Proceedings of the National Academy of Sciences 101.9 (2004): 3065-3070. https://www.pnas.org/doi/abs/10.1073/pnas.0305777101 Chiappini, Barbara, et al. “Identification of prion protein genotype in sheep: 11 years of proficiency tests in Italy.” Accreditation and Quality Assurance 24 (2019): 49-55. https://link.springer.com/article/10.1007/s00769-018-1356-2 Colussi, S., et al. “Absence of the protective alleles AT137RQ and ARQK176 of the PRNP gene, associated with scrapie resistance, in ovine Piedmontese breeds.” Large Animal Review 16.3 (2010). https://www.cabdirect.org/cabdirect/abstract/20103195816 Colussi, S., et al. “Genetic variability of the PRNP gene in Piemonte region goat breeds and in Valdostana breed.” Large Animal Review 14.1 (2008): 11-14. https://www.cabdirect.org/cabdirect/abstract/20083035577 Comoy, Emmanuel E., et al. “Transmission of scrapie prions to primate after an extended silent incubation period.” Scientific reports 5.1 (2015): 11573. https://www.nature.com/articles/srep11573 Corona, Cristiano, et al. “Phenotypical variability in bovine spongiform encephalopathy: Epidemiology, pathogenesis, and diagnosis of classical and atypical forms.” Progress in molecular biology and translational science 150 (2017): 241-265. https://www.sciencedirect.com/science/article/pii/S1877117317300960 Corona, Cristiano, et al. “Olfactory system involvement in natural scrapie disease.” Journal of virology 83.8 (2009): 3657-3667. https://doi.org/10.1128/jvi.01966-08 Dall’Ara, Paola, et al. “Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model.” Life sciences 144 (2016): 226-233. https://www.sciencedirect.com/science/article/pii/S0024320515301016 Djaout, Amal, et al. “Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria.” Journal of genetics 97 (2018): 453-461. https://link.springer.com/article/10.1007/s12041-018-0932-x Dustan, B. H., et al. “A histopathologic and immunohistochemical review of archived UK caprine scrapie cases.” Veterinary pathology 45.4 (2008): 443-454. https://journals.sagepub.com/doi/abs/10.1354/vp.45-4-443 Eraña, Hasier, et al. “Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.” PLoS pathogens 15.10 (2019): e1008117. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008117 Favole, Alessandra, et al. “RT-QuIC detection of pathological prion protein in subclinical goats following experimental oral transmission of L-type BSE.” BMC Research Notes 14 (2021): 1-6. https://link.springer.com/article/10.1186/s13104-021-05859-3 Favole, A., et al. “Early and pre-clinical detection of prion seeding activity in cerebrospinal fluid of goats using real-time quaking-induced conversion assay. Sci. Rep. 2019; 9 (1): 6173.” https://www.nature.com/articles/s41598-019-42449-7 Gonzalez, Lorenzo, et al. “Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe.” Journal of General Virology 91.10 (2010): 2630-2641. https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.022574-0 Iulini, B., et al. “Ten years of BSE surveillance in Italy: neuropathological findings in clinically suspected cases.” Research in Veterinary Science 93.2 (2012): 872-878. https://www.sciencedirect.com/science/article/pii/S0034528811004322 Jacobs, Jorg G., et al. “Molecular discrimination of atypical bovine spongiform encephalopathy strains from a geographical region spanning a wide area in Europe.” Journal of clinical microbiology 45.6 (2007): 1821-1829. https://doi.org/10.1128/jcm.00160-07 Kdidi, Samia, et al. “Genetic Variation in the prion protein gene (PRNP) of two tunisian goat populations.” Animals 11.6 (2021): 1635. https://www.mdpi.com/2076-2615/11/6/1635 Koutsoumanis, K. et al. “EFSA Panel on Biological Hazards (BIOHAZ). Update on chronic wasting disease (CWD) III” (2019) EFSA Journal, 17 (11), art. no. e05863. https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2019.5863 Langeveld, Jan PM, et al. “Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods.” Veterinary research 50.1 (2019): 1-13. https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-019-0718-z Lombardi, Guerino, et al. “Intraspecies transmission of BASE induces clinical dullness and amyotrophic changes.” PLoS Pathogens 4.5 (2008): e1000075. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000075 Marín-Moreno, Alba, et al. “Classical scrapie in small ruminants is caused by at least four different prion strains.” Veterinary research 52.1 (2021): 1-15. https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-021-00929-7 Mazza, Maria, et al. “Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats.” The Journal of general virology 98.7 (2017): 1963. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656779/ Mazza, Maria, et al. “Lysine at position 222 of the goat prion protein inhibits the binding of monoclonal antibody F99/97.6. 1.” Journal of Veterinary Diagnostic Investigation 24.5 (2012): 971-975. https://journals.sagepub.com/doi/abs/10.1177/1040638712457352 Mazza, M., et al. “Co-existence of classical scrapie and Nor98 in a sheep from an Italian outbreak.” Research in veterinary science 88.3 (2010): 478-485. https://www.sciencedirect.com/science/article/pii/S0034528809002719 Meloni, Daniela, et al. “EU-approved rapid tests might underestimate bovine spongiform encephalopathy infection in goats.” Journal of Veterinary Diagnostic Investigation 29.2 (2017): 232-236. https://journals.sagepub.com/doi/abs/10.1177/1040638716688045 Meloni, Daniela, et al. “Reducing the contamination of beef carcasses by specified risk materials during slaughter.” Italian Journal of Food Safety 2.1 (2013): e3-e3. https://pagepressjournals.org/index.php/ijfs/article/view/ijfs.2013.e3 Meloni, Daniela, et al. “EU-approved rapid tests for bovine spongiform encephalopathy detect atypical forms: a study for their sensitivities.” (2012): e43133. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043133 Meloni, Daniela, et al. “Effect of autolysis on the specificity of bovine spongiform encephalopathy rapid tests.” BMC Research Notes 3 (2010): 1-5. https://link.springer.com/article/10.1186/1756-0500-3-193 Nonno, Romolo, et al. “Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains.” Scientific Reports 10.1 (2020): 19. https://www.nature.com/articles/s41598-019-57005-6 Nonno, Romolo, et al. “Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America.” Proceedings of the National Academy of Sciences 117.49 (2020): 31417-31426. https://www.pnas.org/doi/abs/10.1073/pnas.2013237117 Nonno, Romolo, et al. “Variable protease-sensitive prionopathy transmission to bank voles.” Emerging infectious diseases 25.1 (2019): 73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302590/ Orrú, Christina D., et al. “Detection and discrimination of classical and atypical L-type bovine spongiform encephalopathy by real-time quaking-induced conversion.” Journal of clinical microbiology 53.4 (2015): 1115-1120. https://doi.org/10.1128/jcm.02906-14 Otero, Alicia, et al. “A single amino acid substitution, found in mammals with low susceptibility to prion diseases, delays propagation of two prion strains in highly susceptible transgenic mouse models.” Molecular Neurobiology 56 (2019): 6501-6511. https://link.springer.com/article/10.1007/s12035-019-1535-0 Peletto, Simone, et al. “Association of an indel polymorphism in the 3′ UTR of the caprine SPRN gene with scrapie positivity in the central nervous system.” Journal of general virology 93.7 (2012): 1620-1623. https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.041400-0 Peletto, Simone, et al. “Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland.” Journal of Veterinary Science 10.2 (2009): 115-120. https://synapse.koreamed.org/articles/1040964 Pirisinu, Laura, et al. “A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants.” PLoS Pathogens 18.6 (2022): e1010646. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010646 Pirisinu, Laura, et al. “Novel type of chronic wasting disease detected in moose (Alces alces), Norway.” Emerging infectious diseases 24.12 (2018): 2210. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256397/ Poli, Giorgio, et al. “Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie.” Prion 6.1 (2012): 62-72. https://www.tandfonline.com/doi/abs/10.4161/pri.6.1.18317 Porcario, Chiara, et al. “Evaluation of two sets of immunohistochemical and Western blot confirmatory methods in the detection of typical and atypical BSE cases.” BMC research notes 4 (2011): 1-11. https://link.springer.com/article/10.1186/1756-0500-4-376 Sacchi, Paola, et al. “Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats.” Veterinary research 49.1 (2018): 1-13. https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-018-0518-x Sartore, Stefano, et al. “Effect of selection for scrapie resistance on genetic diversity in a rare and locally adapted sheep breed: The case of Sambucana.” Livestock Science 157.1 (2013): 75-80. https://www.sciencedirect.com/science/article/pii/S1871141313003557 Simmons, Marion M., et al. “Transmissible spongiform encephalopathy in goats: is PrP rapid test sensitivity affected by genotype?.” Journal of Veterinary Diagnostic Investigation 32.1 (2020): 87-93. https://journals.sagepub.com/doi/abs/10.1177/1040638719896327 Simmons, M., et al. “Discontools: identifying gaps in controlling bovine spongiform encephalopathy.” Transboundary and emerging diseases 65 (2018): 9-21. https://doi.org/10.1111/tbed.12671 Simmons, Marion M., et al. “L-BSE experimentally transmitted to sheep presents as a unique disease phenotype.” Veterinary Research 47.1 (2016): 112. https://link.springer.com/article/10.1186/s13567-016-0394-1 Spiropoulos, J., et al. “Immunohistochemistry for PrPSc in natural scrapie reveals patterns which are associated with the PrP genotype.” Neuropathology and Applied Neurobiology 33.4 (2007): 398-409. https://doi.org/10.1111/j.1365-2990.2007.00800.x Suardi, Silvia, et al. “Infectivity in skeletal muscle of cattle with atypical bovine spongiform encephalopathy.” PLoS One 7.2 (2012): e31449. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031449 Torricelli, Martina, et al. “PRNP polymorphisms in eight local goat populations/breeds from central and southern Italy.” Animals 11.2 (2021): 333. https://www.mdpi.com/2076-2615/11/2/333 Tranulis, Michael Andreas, et al. “Chronic wasting disease in Europe: new strains on the horizon.” Acta Veterinaria Scandinavica 63.1 (2021): 1-15. https://actavetscand.biomedcentral.com/articles/10.1186/s13028-021-00606-x Tripodi, Letizia, et al. “Chronic Wasting Disease Monitoring in Italy 2017–2019: Neuropathological Findings in Cervids.” Pathogens 11.4 (2022): 401. https://www.mdpi.com/2076-0817/11/4/401 Vallino Costassa, Elena, et al. “Clinical, pathological, and molecular features of classical and L-type atypical-BSE in goats.” Plos one 13.5 (2018): e0198037. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198037 Vallino Costassa, Elena, et al. “Characterization of amyloid-β deposits in bovine brains.” Journal of Alzheimer’s Disease 51.3 (2016): 875. https://content.iospress.com/download?id=10.3233/JAD-151007 Vallino Costassa, Elena,, et al. “Pathogenesis and transmission of classical and atypical BSE in cattle.” Food Safety 4.4 (2016): 130-134. https://www.jstage.jst.go.jp/article/foodsafetyfscj/4/4/4_2016018/_article/-char/ja/ Vanni, Ilaria, et al. “An optimized Western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein.” Journal of Biological Chemistry 299.2 (2023). https://www.jbc.org/article/S0021-9258(22)01266-2/abstract Vanni, Ilaria, et al. “Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease.” Brain 143.5 (2020): 1512-1524. https://academic.oup.com/brain/article-abstract/143/5/1512/5821469 Vidal, Enric, et al. “Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model.” Acta neuropathologica communications 10.1 (2022): 1-22. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-022-01477-7 Vidal, Enric, et al. “Experimental Mycobacterium microti infection in bank voles (Myodes glareolus).” Microorganisms 10.1 (2022): 135. https://www.mdpi.com/2076-2607/10/1/135 Wilson, Rona, et al. “Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein.” Journal of General Virology 93.7 (2012): 1624-1629. https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.042507-0 Xerxa, Elena, et al. “Whole blood gene expression profiling in preclinical and clinical cattle infected with atypical bovine spongiform encephalopathy.” PLoS One 11.4 (2016): e0153425. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153425 Zetterberg, Henrik, et al. “Neurofilaments in blood is a new promising preclinical biomarker for the screening of natural scrapie in sheep.” PLoS One 14.12 (2019): e0226697. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226697 Zoubeyda, Kaouadji, et al. “Variability of the prion protein gene (PRNP) in Algerian dromedary populations.” Animal Gene 17 (2020): 200106. https://www.sciencedirect.com/science/article/pii/S2352406520300063
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