Name: EURL TSE
Telephone: +

Guidelines/best practices

Minimise transmission risk of CJD and vCJD in healthcare settings. Guidance on prevention of CJD and vCJD by the Advisory Committee on Dangerous Pathogens’ Transmissible Spongiform Encephalopathy (ACDP TSE) subgroup https://www.gov.uk/government/publications/guidance-from-the-acdp-tse-risk-management-subgroup-formerly-tse-working-group
WHO infection control guidelines for transmissible spongiform encephalopathies: report of a WHO consultation, Geneva, Switzerland, 23-26 March 1999 https://iris.who.int/bitstream/handle/10665/66707/WHO_CDS_CSR_APH_2000.3.pdf?sequence=1&isAllowed=y
Guide de bonnes pratiques de prevention pour les travaux de recherche sur les prions. Fevrier 2022 https://www.cea.fr/presse/Documents/guide-bonnes-pratiques-prions.pdf
NIH GUIDELINES FOR RESEARCH INVOLVING RECOMBINANT OR SYNTHETIC NUCLEIC ACID MOLECULES – NIH GUIDELINES
ITALIAN REFERENCE LABORATORY BIOSAFETY GUIDELINES
BIOSAFETY IN HANDLING PRIONS FOR DIAGNOSTIC PURPOSED IN ANIMAL HEALTH
PRION AND PRION-LIKE PROTEIN GUIDANCE
LABORATORY BIOSAFETY MANUAL FOURTH EDITION
NOTRE DAME UNIVERSITY BIOSAFETY MANUAL
WORLD HEALTH ORGANIZATION LABORATORY BIOSAFETY MANUAL THIRD EDITION

Literature

Free online scientific publications covering many aspects of biosafety in laboratories working with prions

Chapman, Gail E., et al. “Inactivation of H‐type and L‐type bovine spongiform encephalopathy following recommended autoclave decontamination procedures.” Transboundary and Emerging Diseases 67.5 (2020): 1872-1878. https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.13513
Giles, Kurt, et al. “Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation.” PLoS pathogens 4.11 (2008): e1000206. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000206
Matsuura, Yuichi, et al. “Eliminating transmissibility of bovine spongiform encephalopathy by dry-heat treatment.” Journal of General Virology 101.1 (2020): 136-142. https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001335
Spiropoulos, John, et al. “Incomplete inactivation of atypical scrapie following recommended autoclave decontamination procedures.” Transboundary and emerging diseases 66.5 (2019): 1993-2001. https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.13247
Casassus, Barbara. “France halts prion research amid safety concerns.” (2021): 475-476. https://www.science.org/doi/pdf/10.1126/science.373.6554.475
SAkUdO, AkIkAzU, et al. “Fundamentals of prions and their inactivation.” International journal of molecular medicine 27.4 (2011): 483-489. https://www.spandidos-publications.com/ijmm/27/4/483
Mead, Simon, and Thomas Evans. “Safe laboratory management of prions and proteopathic seeds.” The Lancet Neurology 20.12 (2021): 981. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(21)00379-3/fulltext
Brandel, Jean-Philippe, et al. “Variant Creutzfeldt–Jakob disease diagnosed 7.5 years after occupational exposure.” New England Journal of Medicine 383.1 (2020): 83-85. https://www.nejm.org/doi/full/10.1056/NEJMc2000687
Haybaeck, Johannes, et al. “Aerosols transmit prions to immunocompetent and immunodeficient mice.” PLoS pathogens 7.1 (2011): e1001257. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001257
Bistaffa, Edoardo, et al. “Biosafety of prions.” Progress in Molecular Biology and Translational Science 150 (2017): 455-485. https://www.sciencedirect.com/science/article/abs/pii/S1877117317300984
Caughey, Byron, et al. “Amplified detection of prions and other amyloids by RT-QuIC in diagnostics and the evaluation of therapeutics and disinfectants.” Progress in molecular biology and translational science 150 (2017): 375-388. https://www.sciencedirect.com/science/article/abs/pii/S187711731730073X
Sakudo, Akikazu. “Inactivation methods for prions.” Current Issues in Molecular Biology 36.1 (2020): 23-32. https://www.mdpi.com/1467-3045/36/1/3
Brown, Paul, et al. “Iatrogenic Creutzfeldt-Jakob disease, final assessment.” Emerging infectious diseases 18.6 (2012): 901.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358170/
Waddell, L., et al. “Current evidence on the transmissibility of chronic wasting disease prions to humans—a systematic review.” Transboundary and emerging diseases 65.1 (2018): 37-49.https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.12612
Watson, Neil, et al. “The importance of ongoing international surveillance for Creutzfeldt–Jakob disease.” Nature Reviews Neurology 17.6 (2021): 362-379.https://www.nature.com/articles/s41582-021-00488-7